HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs
نویسندگان
چکیده
منابع مشابه
HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs
Fiber type-specific programs controlled by the transcription factor MEF2 dictate muscle functionality. Here, we show that HDAC4, a potent MEF2 inhibitor, is predominantly localized to the nuclei in fast/glycolytic fibers in contrast to the sarcoplasm in slow/oxidative fibers. The cytoplasmic localization is associated with HDAC4 hyper-phosphorylation in slow/oxidative-fibers. Genetic reprogramm...
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ژورنال
عنوان ژورنال: Molecules and Cells
سال: 2015
ISSN: 1016-8478,0219-1032
DOI: 10.14348/molcells.2015.2278